The use of human pluripotent stem cells in basic and translational cardiac research requires efficient differentiation protocols\ntowards cardiomyocytes. In vitro differentiation yields heterogeneous populations of ventricular-, atrial-, and nodal-like cells\nhindering their potential applications in regenerative therapies.We described the effect of the growth factor Activin A during early\nhuman embryonic stem cell fate determination in cardiac differentiation.Addition of high levels ofActivinAduring embryoid body\ncardiac differentiation augmented the generation of endoderm derivatives, which in turn promoted cardiomyocyte differentiation.\nMoreover, a dose-dependent increase in the coreceptor expression of the TGF-
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